站内搜索:
设为首页 | 加入收藏
|
联系我们 | English | 旧版主页 | 学校主页
 首页  中心概况  技术及服务平台  教学工作  研究队伍  科学研究  人才培养  开放交流  下载中心 
研究队伍
 学术带头人 
 技术人员 
 专家委员 
 客座教授 
您的位置: 首页>研究队伍>客座教授
客座教授简介

客座教授简介

张健教授

一、简介:

张健,教授,医学与生物学研究中心“候鸟”。博士生导师,“百千万人才工程”国家级人选,广西自治区首批八桂学者,南方科技大学特聘教授、美国密歇根大学老年医学研究中心兼职教授,“长寿与老年相关疾病研究”省部共建教育部重点实验室和转化医学研究中心执行主任,广西自治区人民政府参事。张健教授2001年博士毕业于美国密歇根大学病理学专业。

二、主要论文:

1. Zhang J, Dai J, Qi Y, Lin D, Smith P, Strayhorn C, Mizokami A, Fu Z, Westman J, Keller ET. Osteoprotegerin inhibits prostate cancer-induced osteoclastogenesis and prevents prostate tumor growth in the bone.J Clin Invest.107:1235-1244, 2001.

2. Zhang J, Johnston G, Stebler B, Keller ET. Oxidative stress-mediated activation of NFkB and the interleukin-6 promoter requires NFkB-inducing kinase activity. Antioxidant & Redox Signaling. 3:493-504, 2001.

3. Zhang J, Dai J, Lin D, Habib P, Smith P, Murtha J, Fu Z, Yao Z, Qi Y, Keller ET. Osteoprotegerin abrogates chronic alcohol ingestion-induced bone loss in mice. J Bone Miner Res17:1256-1263, 2002.

4. Zhang J, J Dai, Yao Z, Lu Y, Dougall W, Keller ET. Soluble RANK-Fc diminishes prostate tumor progression in bone. Cancer Res. 63:7883-90, 2003

5. Zhang J, Lu Y, Kitazawa R, Kitazawa S, Dai J, Qi W, Zhao X, Yao Z, Hall D, Keller ET. Bioluminescence imaging of RANK ligand transcriptional regulation in vivo.Prostate.59:360-9, 2004

6. Zhang J, Lu Y, O’Brein C, Dai J, Qi W, Hall D, Yao Z, Ershler WB, Keller ET. In vivo visualization of aging-associated gene transcription: evidence for free radical theory of aging. Experimental Gerontology. 39:239-247, 2004

7. Lu Y, Cai Z, Galson DL, Xiao G, Liu YL, George D, Melhem MF, Yao Z and Zhang J*. Monocyte chemotactic protein-1 (MCP-1) acts as a paracrine and autocrine factor for prostate cancer growth and invasion.Prostate. 66:1311-8, 2006

8. Lu Y, Cai Z, Xiao G, Keller ET, Mizokami A, Yao Z, Roodman GD, Zhang J*. Monocyte chemotactic protein-1 (MCP-1) mediates prostate cancer-induced bone resorption.Cancer Res, 67:3646-53, 2007

9. Lu Y, Cai Z, Xiao G, Liu Y, Keller ET, Yao Z, and Zhang J*. CCR2 expression correlates with prostate cancer progression.J Cell Biochem. 101:676-685, 2007

10. Lu Y, Yao Z, and Zhang J*. Prostate cancer bone metastasis: interaction between tumor cells and bone microenvironment. Chin J of Biochem and Molecul Biol,23(3):167-171, 2007

11. Lu Y, Xiao G, Galson DL, Nishio Y, Mizokami A, Yao Z, and Zhang J*. PTHrP-induced MCP-1 production by human bone marrow endothelial cells promotes osteosteoclastast differentiation and prostate cancer cell proliferation and invasion in vitro. Int J of Cancer. 121:724-733, 2007

12. Lu Y, Nie DB, Witt WT, Chen Q, Shen M, Xie H, Lai L, Dai Y, Zhang J*. Expression of the fat-1 gene diminishes prostate cancer growth in vivo through enhancing apoptosis and inhibiting GSK-3β phosphorylation.Mol Cancer Therapeutics, 7(10):3203-11, 2008

13. Lu Y, Wang J, Xu Y, Koch AE., Cai Z, Chen X, Galson DL, Taichman RS, and Zhang J*. CXCL16 functions as a novel chemotactic factor for prostate cancer cells in vitro.Mol Cancer Res, 6(4): 546-54, 2008

14. Lu Y, Chen QY, Corey E, Xie W, Fan J, Dai J, Mizokami A, andZhang J*. Activation of MCP-1/CCR2 axis promotes prostate cancer growth in bone.Clin Exp Metastasis, 26(2):161-9, 2009

15. Cai Z, Chen QY, Chen J, Lu Y, Xiao GZ, and Zhang J*. MCP-1 promotes lung cancer-induced bone resorptive lesions in vivo. Neoplasia, 11(3):228-236, 2009

16. Zhang J, Patel L, and Pienta KJ. CC chemokine ligand 2 (CCL2) promotes prostate cancer tumorigenesis and metastasis.Cytokine Growth Factor Rev. 2010 Feb;21(1):41-8.

17. Zhang J, Lu Y, and Pienta KJ. Multiple roles of CC chemokine ligand 2 (CCL2) in promoting prostate cancer growth.J Natl Cancer Inst. 2010 Apr 21;102(8):522-8.

18. Zhang J*, Sud S, Mizutani K, Gyetko MR, and Pienta KJ. Activation of urokinase plasminogen activator (uPA) and its receptor (uPAR) axis is essential for macrophage infiltration in a prostate cancer mouse model. In press,Neoplasia2011

19. Hongwei Guo, Chenxia Yun, Guanghan Hou, Jun Du, Xin Huang, Yi Lu, Evan T. Keller, Jian Zhang*, Jiagang Deng*,Mangiferin attenuates Th1/Th2 cytokine imbalance in an ovalbumin-induced asthmatic mouse model.Plos one. 2014.

20. Huajiao Guo, Yi Lu, Jianhua Wang, Xia Liu, Evan T. Keller, Qian Liu, Qinghua Zhou, Jian Zhang*, Targeting Notch Signaling Pathway in Cancer Therapeutics.Thoracic Cancer, 2014, In Press.

21. Guo HW, Yun CX, Hou GH, Du J, Huang X, Lu Y, Keller ET, Zhang J, Deng JG.Mangiferin attenuates TH1/TH2 cytokine imbalance in an ovalbumin-induced asthmatic mouse model.Plos One. 2014, 9 (6): 331-338.

22. Wang SY, ZouCL, FuLL, WangB, AnJ, SongGR, WuJY, TangXH, LiM, ZhangJ, YueF, ZhengCG, ChanP, Zhang YA,ChenZG. Autologous iPSC-derived dopamine neuron transplantation in a nonhuman primate Parkinson’s disease model. Cell Discovery. 2015, 1-11.

王毅研究员

一、简介

王毅,研究员,医学与生物学研究中心“候鸟”。现任中国科学院生物物理研究所脑与认知科学国家重点实验室研究员,创新课题组组长,具有多年国外学习和工作经历,承担并参与自然科学、863、973等基金资助的科研课题,在Nature、Nature Neuroscience、Cerebral Cortex等SCI收录的权威杂志上发表了多篇重要学术论文。

二、主要论文:

1. Li Ran, Wang Yi* (2013) Neural mechanism for sensing fast motion in dim light. Scientific Reports 3, 3159 (*corresponding author).

2. Dai Ji, Wang Yi* (2012) Representation of surface luminance and contrast in primary visual cortex. Cerebral Cortex 22:776-787 (*corresponding author).

3. Lim Heejin#, Yi Wang#, Xiao Youping#, Hu Ming, Felleman Daniel J (2009) Organization of hue selectivity in macaque V2 thin stripes. Journal of Neurophysiology 102, 2603-2615

(# these authors contributed equally to this work).

4. Wang Yi, Xiao Youping, Felleman Daniel J (2007) V2 thin stripes contain spatially organized representations of achromatic luminance change. Cerebral Cortex 17:116-129 (The cover figure of the issue of 2007 Jan).

5. Xiao Youping, Wang Yi, Felleman Daniel J (2003) A spatially organized representation of color in macaque area V2. Nature 421:535-539 (See the comments of B Conway in Current Biology 2003, 13:R308-R310).

6. Wang Yi, Fujita Ichiro, Tamura Hiroshi, Murayama Yusuke (2002) Contribution of GABAergic inhibition to receptive field structures of monkey inferior temporal neurons. Cerebral Cortex 12:62-74.

7. Wang Yi, Fujita Ichiro, Murayama Yusuke (2000) Neuronal mechanisms of selectivity for object features revealed by blocking inhibition in inferotemporal cortex. Nature Neuroscience 3:807-813 (See the comments of B Jagadeesh in Nature Neuroscience 2000, 3:749-750 on this paper)

8. Li Bing, Wang Yi, Diao Yun-cheng (1994) Quantification of directional and orientational selectivities of the visual neurons to moving stimuli. Biological Cybernetics 70, 281-290.

周劲松教授

一、简介

周劲松,女,博士,教授,医学与生物学研究中心“候鸟”。毕业于湖南医科大学,在美国拉什大学攻读博士学位,美国范德比尔特大学博士后,现为美国Kansas City University of Medicine and Bioscience教授,主要从事分子生物物理与生理学研究。先后在国外期刊上发表文章40余篇。

二、基金

(PI) “Ca2+ signaling in progression of amyotrophic lateral sclerosis in skeletal muscle”, NIH:NIAMSD, R01 (AR057404), 2010 ~ 2015.

NIH: T32HL007692 (Director: John Solaro at University of Illinois) 7/1/2010 – 6/30/2015; Dr. Zhou is a trainer in this grant. Chehade Karam (Zhou’s Postdoctoral fellow) receives a fellowship of $ 53,782/year.

(PI). “Mitochondrial defects in neurodegenerative diseases” Bank of American (equipment support). $82,225. 2015

(PI) “Target Microbiota to alleviate ALS progression”. ALS Association. World Research Award 288. 2015 ~ 2016.

(PI). “Bone defects in Amyotrophic Lateral Sclerosis”. Bank of American Victor E. Speas Foundation.2015 ~ 2016

三、主要论文

1. Zhou J, Yi J, Bonewald L. (2015). Muscle-Bone Crosstalk in Amyotrophic Lateral Sclerosis.Curr Osteoporos Rep. 2015 Jul 30. [Epub ahead of print]

2. Zhang YG, Wu S, Lu R, Zhou D, Zhou J, Carmeliet G, Petrof E, Claud EC, Sun J. (2015). Tight junction CLDN2 gene is a direct target of the vitamin D receptor.Scientific Report. In press.

3. Ding Y, Fang H, Shang W, Xiao Y, Sun T, Hou N, Pan L, Sun X, Ma Q, Zhou J, Wang X, Zhang X, Cheng H. Mitoflash altered by metabolic stress in insulin-resistant skeletal muscle.2015.J Mol Med(Berl). [Epub ahead of print]. PMID: 25908643

4. Wu S, Yi J, Zhang YG, Zhou J* and Sun J*. Leaky intestine and impaired microbiome in an amyotrophic lateral sclerosis mouse model. (2015).Physiological Report. 3(4), e12356. (*Zhou and Sun are Co-correspondingauthors). PMID: 25847918

5. Zhu K, Yi J, Xiao Y, Lai Y, Song P, Zheng W, Jiao H, Fan J, Wu C, Chen d,Zhou J* and Xiao G*. (2015).Impaired Bone Homeostasis in Amyotrophic Lateral Sclerosis Mice with Muscle Atrophy.J Biol Chem. 27:290 (13): 8081-94.(* Zhou and Xiao are Co-corresponding Authors).

6. Xiao Y, Ma C, Yi J, Wu S, Luo G, Xu X, Lin P-H, Sun J and Zhou J. (2015). Suppressed Autophagy Flux in Skeletal Muscle of an Amyotrophic Lateral Sclerosis Mouse Model during Disease Progression.Physiology Report. 3(1) e12271, doi:10.14814/phys2.12271

7. Doscas ME, Williamson AJ, Usha L, Bogachkov Y, Rao GS, Xiao F, Wang Y, Ruby C, Kaufman H, Zhou J, Williams JW, Li Y, Xu X. (2014). Inhibition of p70 S6 Kinase (S6K1) Activity by A77 1726 and Its Effect on Cell Proliferation and Cell Cycle Progress.Neoplasia. 16(10): 824-34. doi: 10.1016/j.neo.

8. Park KH, Weisleder N, Zhou J, Gumpper K, Zhou X, Ma J and Lin PH. (2014). Assessment of Calcium Sparks in Intact Skeletal Muscle Fibers.J Vis Exp. (84):e50898. doi: 10.3791/50898. PMID: 24638093

9. Luo G, Yi J, Ma C, Xiao Y, Yi F, Yu T and Zhou J. (2013). Defective mitochondrial dynamics is an early event in skeletal muscle of an amyotrophic lateral sclerosis mouse model.PLoS One. 8(12):e82112. doi: 10.1371/journal. pone.0082112.

10. Manno C, Figueroa L, Royer L, Pouvreau S, Lee CS, Volpe P, Nori A, Zhou J, Meissner G, Hamilton SL, Rios E. (2013). Altered Ca2+concentration, permeability and buffering in the myofiber Ca2+store of a mouse model of malignant hyperthermia.J Physiol. 15;591(Pt 18):4439-57.

11. Figueroa L, Shkryl VM, Zhou J, Manno C, Momotake A, Brum G, Blatter LA, Ellis-Davies G CR, and Rios E. (2012). Synthetic localized calcium transients directly probe signaling mechanisms in skeletal muscle.J Phyisol, 590:1389-411.

12. Tjondrokoesoemo A, Park KH, Ferrante C, Komazaki S, Lesniak S, Brotto M, Ko JK, Zhou J, Weisleder N, Ma J. (2011). Disrupted membrane structure and intracellular Ca signaling in adult skeletal muscle with acute knockdown of bin1.PLoS One. 6(9):e25740.

13. Yi J, Ma C, Li Y, Weisleder N, Ríos E, Ma J, Zhou J. (2011). Mitochondrial Calcium Uptake Regulates Rapid Calcium Transients in Skeletal Muscle during Excitation-Contraction (E-C) Coupling.J BiolChem. 286:32436-43.

14. Weisleder N, Zhou J, and Ma J. (2012). Detection of Calcium Sparks in Intact and Permeabilized Skeletal Muscle Fibers. Book Chapter in Myogenesis. 1st Edition. Series of “Methods in MolecularBiology”. Vol. 798.Springer,Editor: DiMario, Joseph X.

15. Sztretye M, Yi J, Figueroa L, Zhou J, Royer L, Allen P, Brum G and Ríos E. (2011). Measurement of RyR permeability reveals a role of calsequestrin in termination of SR Ca2+ release in skeletal muscle.J Gen Physiol. 138:231-47.

16. Sztretye M, Yi J, Figueroa L, Zhou J, Royer L, Ríos E. (2011). D4cpv-calsequestrin: a sensitive ratiometric biosensor accurately targeted to the calcium store of skeletal muscle.J Gen Physiol. 138:211-29.

17. Fang H, Chen M, Ding Y, Shang W, Xu J, Zhang X, Zhang W, Li K, Xiao Y, Gao F, Shang S, Li J-C, Tian X-L, Wang S-Q, Zhou J, Weisleder N, Ma J, Ouyang K, Chen J, Wang X, Zheng M, Wang W, Zhang X, Cheng H. (2011). Imaging superoxide flash and metabolism-coupled mitochondrial permeability transition in living animals.Cell Research(2011):1-10.

刘杰教授

一、简介

刘杰,博士,教授,硕士研究生导师,是遵义医学院的“候鸟”。现为美国堪萨斯大学医学研究中心(University of Kansas Medical Center)教授。主要从事药理与毒理学研究。在国外期刊发表药理、毒理论文200余篇及著作多部,如刚出版的Casarett & Doull’s Toxicology国际通用毒理教科书。国际几种主要药理毒理刊物Toxicological Sciences, Experimental & Biology Medicine,Environmental Health Perspectives编委。现为遵义医学院药理学教研室教授,贵州省基础药理重点实验室副主任。现主持省科技厅中药现代化、省高层次人才项目,指导完成国家自然科学基金项目、省中医药管理局、省科技厅攻关项目、省国际合作项目10多项。

二、主要论文

1. Jing XH, Liu J, Hou WY, Gao Y. Age-related changes in renal AQP3 and AQP4 expression in Sprague Dawley rats. Genetics and Molecular Research. 2016.

2. Li H, Li WK, Lu YF, Wei LX, Liu J. The Tibetan medicine Zuotai influences clock gene expression in the liver of mice. PeerJ. 2016 Jan 26;4:e1632.

3. Wu, Q., Li, W.K, Zhou, Z. P., Li, Y.Y., Xiong, T.W., Du, Y.Z., Wei L.X., Liu, J., 2016. The Tibetan medicine Zuotai differs from HgCl2 and MeHg in producing liver injury in mice. Regul. Toxicol. Pharmacol. 2016 Mar 28;78:1-7.

4. Wu KC, McDonald PR, Liu J, Klaassen CD. Screening of natural compounds as activators of the Keap1-Nrf2 pathway. Planta Med. 80(1), 97-104, 2014.

5. Wu Q Zhang D, Tao N, Zhu QN, Shi JS, Liu J. Induction of metallothionein and the Nrf2-target genes mediates heptoprotective effects of Piper puberllum (Benth. ) Maxim. Am J Chin Med. 42(1), 207-221, 2014.

6. Xu SF, Jin T, Lu YF, Li LS, Liu J, Shi JS. Effect of icariin on UDP-glucuronosyltransferases in mouse liver. Planta Med. 80(5), 387-392, 2014.

7. Qin Y, Wang H, Liu ZY, Liu J, Wu JZ. Realgar quantum dots induce apoptosis and necrosis in HepG2 cells through endoplasmic reticulum stress. Biomed Rep. 2015 Sep;3(5):657-662. Epub 2015 Jul 15.

8. Wang H, Liu Z, Gou Y, Qin Y, Xu Y, Liu J, Wu JZ. Apoptosis and necrosis induced by novel realgar quantum dots in human endometrial cancer cells via endoplasmic reticulum stress signaling pathway. Int J Nanomedicine. 2015 Aug 31;10:5505-12.

9. Cheng ML, Lu YF, Chen H, Shen ZY, Liu J. Liver expression of Nrf2-related genes in different liver diseases. Hepatobiliary Pancreat Dis Int. 2015 Oct;14(5):485-91.

10. Lu YF, Liu J, Wu KC, Qu Q, Fan F, Klaassen CD. Overexpression of Nrf2 protects against microcystin-induced hepatotoxicity in mice. PLoS One. 9(3), e93013, 2014.

11. Qu Q, Liu J, Zhou HH, Klaassen CD. Nrf2 protects against furosemide-induced hepatotoxicity. Toxicology 324, 35-42, 2014.

12. Cheng X, Vispute SG, Liu J, Cheng C, Kharitonenkov A, Klaassen CD. Fibroblast growth factor (Fgf) 21 is a novel target gene of the aryl hydrocarbon receptor (AhR). Toxicol Appl Pharmacol. 278(1), 65-71, 2014.

13. Chen H, Shen ZY, ,u W, Fan TY, Li J, Lu YF, Cheng ML, Liu J. Expression of P450 and nuclear receptors in normal and end-stage Chinese livers. World J Gastroenterol. 20(26), 8681-8690, 2014.

14. Liu, J, Lu H, Lu YF, Lei XH, Cui JY, Ellis E,Strom SC, Klaassen CD. Potency of Individual bile acids to regulate bile acid synthesis and transport genes in primary human hepatocyte cultures. Toxicol Sci. 141(2), 538-546, 2014.

15. Hou WY, Xu SF, Zhu QN, Lu YF, Cheng XG, Liu J. Age-and sex-related differences of organic anion-transporting polypeptide gene expression in livers of rats. Toxicol. Appl. Pharmacol. 280(2), 370-377, 2014.

16. Lu Y-F, Wu CK, Liu J, Klaassen CD. Protection against phalloidin-induced liver injury by oleanolic acid involves Nrf2 activation and suppression of Oatp1b2. Toxicol Lett. 232(1), 326-332, 2014

17. Lu Y-F, Xu Y-Y, Jin F, Wu Q, Liu J, Shi J-S. Icariin is a PPARα activator inducing lipid metabolic gene expression. Molecules, 19 (11), 18179-18191, 2014.